Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI.
Opticin is a class III member of the extracellular matrix small leucine-rich repeat protein/proteoglycan (SLRP) family found in vitreous humour and cartilage.It was first identified associated with the surface of vitreous collagen fibrils and several Bottles/Triggers other SLRPs are also known to bind collagen fibrils and it some cases alter fibril